Publikationen

Ausgewählte Publikationen der vergangenen drei Jahre

Binder J, Held J, Krappmann S (2019) Impairing fluoride export of Aspergillus fumigatus mitigates its voriconazole resistance. Int J Antimicrob Agents 53: 689-693.

Bogdan C, Debus A, Sebald H, Rai B, Schäfer J, Obermeyer S, Schleicher U (2019) Experimental cutaneous leishmaniasis: mouse models for resolution of inflammation versus chronicity of disease. Methods Mol Biol 1971: 315-349.

Bruns H, Jitschin S, Gamali S, Saul D, Böttcher M. Mackensen A, Jitschin R, Mougiakakos D (2019) A novel immunoregulatory function of β-2-microglobulin as a promoter of myeloid derived suppressor cell induction. Leukemia 33: 1282-1287.

Full F, van Gent M, Sparrer KMJ, Chiang C, Zurenski MA, Scherer M, Brockmeyer NH, Heinzerling L, Stürzl M, Korn K, Stamminger T, Ensser A, Gack MU (2013) Centrosomal protein TRIM43 restricts herpesvirus infection by regulating nuclear lamina integrity. Nat Microbiol 4: 164-176.

Hansen M, Peltier J, Killy B, Amin B, Bodendorfer B, Härtlova A, Uebel S, Bosmann M, Hofmann J, Büttner C, Ekici AB, Kuttke M, Franzyk H, Foged C, Beer-Hammer S, Schabbauer G, Trost M, Lang R (2019) Macrophage phosphoproteome analysis reveals MINCLE-dependent and -independent mycobacterial cord factor signaling. Mol Cell Proteomics 18: 669-685.

Hayek I, Berens C, Lührmann A (2019) Modulation of host cell metabolism by T4SS-encoding intracellular pathogens. Curr Opin Microbiol 47: 59-65.

Hayek I, Fischer F, Schulze-Luehrmann J, Dettmer K, Sobotta K, Schatz V, Kohl L, Boden K, Lang R, Oefner PJ, Wirtz S, Jantsch J, Lührmann A (2019) Limitation of TCA cycle intermediates represents an oxygen-independent nutritional antibacterial effector mechanism of macrophages. Cell Rep 26: 3502-3510.

Heß R, Storcksdieck Genannt Bonsmann M, Lapuente D, Maaske A, Kirschning C, Ruland J, Lepenies B, Hannaman D, Tenbusch M, Überla K (2019) Glycosylation of HIV env impacts IgG subtype responses to vaccination. Viruses 11: E153.

Jeninga MD, Quinn JE, Petter M (2019) ApiAP2 transcription factors in apicomplexan parasites. Pathogens 8: E47.

Kohl L, Hayek I, Daniel C, Schulze-Lührmann J, Bodendorfer B, Lührmann A, Lang R (2019) MyD88 is required for efficient control of Coxiella burnetii infection and dissemination. Front Immunol 10: 165.

Krljanac B, Schubart C, Naumann R, Wirtz S, Culemann S, Krönke G, Voehringer D (2019) RELMα-expressing macrophages protect against fatal lung damage and reduce parasite burden during helminth infection. Sci Immunol 4: eaau3814.

Möller J, Kraner ME, Burkovski A (2019) More than a toxin: protein inventory of Clostridium tetani toxoid vaccines. Proteomes 7: E15.

Muller I, Jex AR, Kappe SHI, Mikolajczak SA, Sattabongkot J, Patrapuvich R, Lindner S, Flannery EL, Koepfli C, Ansell B, Lerch A, Emery-Corbin SJ, Charnaud S, Smith J, Merrienne N, Swearingen KE, Moritz RL, Petter M, Duffy MF, Chuenchob V (2019) Transcriptome and histone epigenome of Plasmodium vivax salivary-gland sporozoites point to tight regulatory control and mechanisms for liver-stage differentiation in relapsing malaria. Int J Parasitol pii: S0020-7519(19)30085-2.

Neddermann M, Backert S (2019) How many protein molecules are secreted by single Helicobacter pylori cells: Quantification of serine protease HtrA. Cell Microbiol e13022.

O’Donnell VB, Aldrovandi M, Murphy RC, Krönke G (2019) Enzymatically oxidized phospholipids assume center stage as essential regulators of innate immunity and cell death. Sci Signal 12: eaau2293.

Paduch K, Debus A, Rai B, Schleicher U, Bogdan C (2019) Resolution of cutaneous leishmaniasis and persistence of Leishmania major in the absence of arginase 1. J Immunol 202: 1453-1464.

Pönisch W, Weber CA, Zaburdaev V (2019) How bacterial cells and colonies move on solid substrates. Phys Rev E 99: 042419.

Elsayed H, Nabi G, McKinstry WJ, Khoo KK, Mak J, Salazar AM, Tenbusch M, Temchura V, Überla K (2018) Intrastructural help: harnessing T helper cells induced by licensed vaccines for improvement of HIV env antibody responses to virus-like particle vaccines. J Virol 92: e00141-18.

Kindermann M, Knipfer L, Atreya I, Wirtz S (2018) ILC2s in infectious diseases and organ-specific fibrosis. Semin Immunopathol 40: 379-392.

Korn K, Coras R, Bobinger T, Herzog SM, Lücking H, Stöhr R, Huttner HB, Hartmann A, Ensser A (2018) Fatal encephalitis associated with Borna disease virus 1. N Engl J Med 379: 1375-1377.

Lucas S, Omata Y, Hofmann J, Böttcher M, Iljazovic A, Sarter K, Albrecht O, Schulz O, Krishnacoumar B, Krönke G, Herrmann M, Mougiakakos D, Strowig T, Schett G, Zaiss MM (2018) Short-chain fatty acids regulate systemic bone mass and protect from pathological bone loss. Nat Commun 9: 55.

Meng X, Grötsch B, Luo Y, Knaup KX, Wiesener MS, Chen XX, Jantsch J, Fillatreau S, Schett G, Bozec A (2018) Hypoxia-inducible factor-1α is a critical transcription factor for IL-10-producing B cells in autoimmune disease. Nat Commun 9: 251.

Messlinger H, Sebald H, Heger L, Dudziak D, Bogdan C, Schleicher U (2018) Monocyte-derived signals activate human natural killer cells in response to Leishmania parasites. Front Immunol 9: 24.

Pönisch W, Eckenrode K B, Alzurqa K, Nasrollahi H, Weber C, Zaburdaev V, Biais N (2018) Pili mediated intercellular forces shape heterogeneous bacterial microcolonies prior to multicellular differentiation. Sci Rep 8: 16567.

Schleicher U, Liese J, Justies N, Mischke T, Haeberlein S, Sebald H, Kalinke U, Weiss S, Bogdan C (2018) Type I interferon signaling is required for CpG-oligodesoxy-nucleotide-induced control of Leishmania major, but not for spontaneous cure of subcutaneous cure of primary and secondary L. major infection. Front Immunol 9: 79.

Schubart C, Krljanac B, Otte M, Symowski C, Martini E, Günther C, Becker C, Daniel C, Voehringer D (2018) Selective expression of constitutively activated STAT6 in intestinal epithelial cells promotes differentiation of secretory cells and protection against helminths. Mucosal Immunol 12: 413-424.

Wehrstedt S, Kubis J, Zimmermann A, Bruns H, Mayer D, Grieshober M, Stenger S (2018) The tyrosine kinase inhibitor dasatinib reduces the growth of intracellular Mycobacterium tuberculosis despite impairing T-cell function. Eur J Immunol 48: 1892-1903.

Willebrand R, Dietschmann A, Nitschke L, Krappmann S, Voehringer D (2018) Murine eosinophil development and allergic lung eosinophilia are largely dependent on the signaling adaptor GRB2. Eur J Immunol 48: 1786-1795.

Ackermann JA, Hofheinz K, Zaiss MM, Krönke G (2017) The double-edged role of 12/15-lipoxygenase during inflammation and immunity. Biochim Biophys Acta Mol Cell Biol Lipids 1862: 371-381.

Full F, Hahn AS, Großkopf AK, Ensser A (2017) Gammaherpesviral tegument proteins, PML-nuclear bodies and the ubiquitin-proteasome system. Viruses 9: E308.

Lamm CE, Kraner ME, Hofmann J, Börnke F, Mock HP, Sonnewald U (2017) Hop/Sti1 – A two-faced cochaperone involved in pattern recognition receptor maturation and viral infection. Front Plant Sci 8: 1754.

Leitherer S, Clos J, Liebler-Tenorio EM, Schleicher U, Bogdan C, Soulat D (2017) Characterization of the protein tyrosine phosphatase LmPRL-1 secreted by Leishmania major via the exosome pathway. Infect Immun 85: e00084-17.

Ostrop J, Lang R (2017) Contact, collaboration, and conflict: signal integration of Syk-coupled C-Type lectin receptors. J Immunol 198: 1403-14.

Pönisch W, Weber CA, Juckeland G, Biais N, Zaburdaev V (2017). Multiscale modeling of bacterial colonies: how pili mediate the dynamics of single cells and cellular aggregates. New Journal of Physics 19: 015003.

Reuter N, Schilling EM, Scherer M, Müller R, Stamminger T (2017) The ND10 component promyelocytic leukemia protein acts as an E3 ligase for SUMOylation of the major immediate early protein IE1 of human cytomegalovirus. J Virol 91: pii: e02335-16.

Schäfer W, Eckart R A, Schmid B, Cagköylü H, Hof K, Muller Y A, Amin B, Lührmann A (2017) Nuclear trafficking of the anti-apoptotic Coxiella burnetii effector protein AnkG requires binding to p32 and Importin-alpha1. Cell Microbiol 19: e12634.

Schick J, Etschel P, Bailo R, Ott L, Bhatt A, Lepenies B, Kirschning C, Burkovski A, Lang R (2017) Toll-Like receptor 2 and Mincle cooperatively sense corynebacterial cell wall glycolipids. Infect Immun 85: e00075-17.

Soulat D, Bogdan C (2017) Function of macrophage and parasite phosphatases in leishmaniasis. Front Immunol 8: 1838.

Strelnikova N, Sauter N, Guizar-Sicairos M, Göllner M, Diaz A, Delivani P, Chacón M, Tolić IM, Zaburdaev V, Pfohl T (2017) Live cell X-ray imaging of autophagic vacuoles formation and chromatin dynamics in fission yeast. Sci Rep 7: 13775.

Tegtmeyer N, Wessler S, Necchi V, Rohde M, Harrer A, Rau TT, Asche CI, Boehm M, Loessner H, Figueiredo C, Naumann M, Palmisano R, Solcia E, Ricci V, Backert S (2017) Helicobacter pylori employs a unique basolateral type IV secretion mechanism for CagA delivery. Cell Host Microbe 22: 552-560.

Temchura V, Überla K (2017) Intrastructural help: improving the HIV-1 envelope antibody response induced by virus-like particle vaccines. Curr Opin HIV AIDS 12: 272-277.

Uderhardt S, Ackermann JA, Fillep T, Hammond VJ, Willeit J, Santer P, Mayr M, Biburger M, Miller M, Zellner KR, Stark K, Zarbock A, Rossaint J, Schubert I, Mielenz D, Dietel B, Raaz-Schrauder D, Ay C, Gremmel T, Thaler J, Heim C, Herrmann M, Collins PW, Schabbauer G, Mackman N, Voehringer D, Nadler JL, Lee JJ, Massberg S, Rauh M, Kiechl S, Schett G, O’Donnell VB, Krönke G (2017) Enzymatic lipid oxidation by eosinophils propagates coagulation, hemostasis, and thrombotic disease. J Exp Med 214: 2121-2138.

Wirtz S, Popp V, Kindermann M, Gerlach K, Weigmann B, Fichtner-Feigl S, Neurath MF (2017) Chemically induced mouse models of acute and chronic intestinal inflammation. Nat Protoc 12: 1295-1309.

Amich J, Dümig M, O’Keeffe G, Binder J, Doyle S, Beilhack A, Krappmann S (2016) Exploration of sulfur assimilation of Aspergillus fumigatus reveals biosynthesis of sulfur-containing amino acids as a virulence determinant. Infect Immun 84: 917-929.

Bisle S, Klingenbeck L, Borges V, Sobotta K, Schulze-Luehrmann J, Menge C, Heydel C, Gomes JP, Lührmann A (2016) The inhibition of the apoptosis pathway by the Coxiella burnetii effector protein CaeA requires the EK repetition motif, but is independent of survivin. Virulence 7: 400-412.

Broecker F, Martin CE, Wegner E, Mattner J, Baek JY, Pereira C L, Anish C, Seeberger PH (2016) Synthetic lipoteichoic acid glycans are potential vaccine candidates to protect from Clostridium difficile infections. Cell Chem Biol 23: 1014-1022.

Eberle JU, Voehringer D (2016) Role of basophils in protective immunity to parasitic infections. Semin Immunopathol 38: 605-613.

Hacker E, Ott L, Schulze-Luehrmann J, Lührmann A, Wiesmann V, Wittenberg T, Burkovski A (2016) The killing of macrophages by Corynebacterium ulcerans. Virulence 7: 45-55.

Hahn AS, Großkopf AK, Jungnickl D, Scholz B, Ensser A (2016) Viral FGARAT homolog ORF75 of rhesus monkey rhadinovirus effects proteasomal degradation of the ND10 components SP100 and PML. J Virol 90: 8013-8028.

Hilpert C, Sitte S, Matthies A, Voehringer D (2016) Dendritic cells are dispensable for T cell priming and control of acute lymphocytic choriomeningitis virus infection. J Immunol 197: 2780-2786.

Huber A, Kallerup R S, Korsholm K S, Franzyk H, Lepenies B, Christensen D, Foged C Lang R (2016) Trehalose diester glycolipids are superior to the monoesters in binding to Mincle, activation of macrophages in vitro and adjuvant activity in vivo. Innate Immun 22: 405-418.

Hupfer T, Schick J, Jozefowski K, Voehringer D, Ostrop J, Lang R (2016) Stat6-Dependent inhibition of Mincle expression in mouse and human antigen-presenting cells by the Th2 cytokine IL-4. Front Immunol 7: 423.

Krappmann S (2016) How to invade a susceptible host: cellular aspects of aspergillosis. Curr Opin Microbiol 34: 136-146.

Mahapatro M, Foersch S, Hefele M, He G W, Giner-Ventura E, McHedlidze T, Kindermann M, Vetrano S, Danese S, Günther C, Neurath M F, Wirtz S, Becker C (2016) Programming of intestinal epithelial differentiation by IL-33 derived from pericryptal fibroblasts in response to systemic infection. Cell Reports 15: 1743-1756.

Mattner J, Schmidt F, Siegmund B (2016) Faecal microbiota transplantation – a clinical view. Int J Med Microbiol 306: 310-315.

Sasse A, Hamer S N, Amich J, Binder J, Krappmann S (2016) Mutant characterization and in vivo conditional repression identify aromatic amino acid biosynthesis to be essential for Aspergillus fumigatus virulence. Virulence 7: 56-62.

Schatz V, Strüssmann Y, Mahnke A, Schley G, Waldner M, Ritter U, Wild J, Willam C, Dehne N, Brüne B, McNiff J M, Colegio OR, Bogdan C, Jantsch J (2016) Myeloid cell-derived HIF-1α promotes control of Leishmania major. J Immunol 197: 4034-41.

Schey R, Dornhoff H, Baier JL, Purtak M, Opoka R, Koller AK, Atreya R, Rau TT, Daniel C, Amann K, Bogdan C, Mattner J (2016) CD101 inhibits the expansion of colitogenic T cells. Mucosal Immunol 9: 1205-1217.

Schleicher U, Paduch K, Debus A, Obermeyer S, König T, Kling JC, Ribechini E, Dudziak D, Mougiakakos D, Murray PJ, Ostuni R, Körner H, Bogdan C (2016) TNF-mediated restriction of arginase 1 expression in myeloid cells triggers type 2 NO synthase activity at the site of infection. Cell Rep 15: 1062-1075.

Storcksdieck genannt Bonsmann M, Niezold T, Hannaman D, Überla K, Tenbusch M (2016) The improved antibody response against HIV-1 after a vaccination based on intrastructural help is complemented by functional CD8⁺ T cell responses. Vaccine 34: 1744-1751.

Zaiss MM, Harris NL (2016) Interactions between the intestinal microbiome and helminth parasites. Parasite Immunol 38: 5-11.